Selected publications

Discover a selection of our most recent and insightful publications.

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Does stimulant drug-induced sensitization occur in primates?

Leyton M. (2022). Does stimulant drug-induced sensitization occur in primates?. Journal of psychiatry & neuroscience : JPN, 47(2), E148–E152. https://doi.org/10.1503/jpn.220055

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model.

Leyton, M., & Vezina, P. (2014). Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model. Trends in pharmacological sciences, 35(6), 268–276. https://doi.org/10.1016/j.tips.2014.04.002

The netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.

Vosberg, D. E., Leyton, M., & Flores, C. (2020). The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence. Molecular psychiatry, 25(2), 297–307. https://doi.org/10.1038/s41380-019-0561-7

Extra-striatal dopamine2/3 receptor availability in youth at-risk for addictions.

Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M. Extra-striatal D2/3 receptor availability in youth at risk for addiction. Neuropsychopharmacology. 2020 Aug;45(9):1498-1505. doi: 10.1038/s41386-020-0662-7. Epub 2020 Apr 7. PMID: 32259831; PMCID: PMC7360619.

Externalizing risk pathways for substance use problems.

Cox, S., Castellanos-Ryan, N., Parent, S., Benkelfat, C., Vitaro, F., Pihl, R. O., Boivin, M., Tremblay, R. E., Leyton, M., & Séguin, J. R. (2021). Externalizing Risk Pathways for Adolescent Substance Use and Its Developmental Onset: A Canadian Birth Cohort Study: Trajectoires de comportements extériorisés et le risque pour l'initiation et l'usage de substances des adolescents : Une étude de cohorte de naissance canadienne. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 66(10), 887–896. https://doi.org/10.1177/0706743720982429

A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine.

Iqbal, M., Cox, S., Jaworska, N., Tippler, M., Castellanos-Ryan, N., Parent, S., Dagher, A., Vitaro, F., Brendgen, M. R., Boivin, M., Pihl, R. O., Côté, S. M., Tremblay, R. E., Séguin, J. R., & Leyton, M. (2022). A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 47(3), 752–758. https://doi.org/10.1038/s41386-021-01187-z

Reduced dopamine response to amphetamine in subjects at ultra high risk for addiction

Casey, K. F., Benkelfat, C., Cherkasova, M. V., Baker, G. B., Dagher, A., & Leyton, M. (2014). Reduced dopamine response to amphetamine in subjects at ultra-high risk for addiction. Biological psychiatry, 76(1), 23–30. https://doi.org/10.1016/j.biopsych.2013.08.033

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